Annie Murphys past projects have included Rookie Blue, Flashpoint, Good God, The Story of Jen, Beauty and the Beast, and Blue Mountain State. Murphy has also worked in theatre in Montreal and Toronto.

Murphy is currently starring in the Emmy-nominated Schitts Creek for CBC/ITV. She stars alongside Eugene Levy, Daniel Levy, Catherine OHara, and Chris Elliott as Alexis Rose, the daughter of Eugene Levy and OHara.  Murphy was first nominated in 2016 for a Canadian Screen Award for Best Actress in a Comedy for her work on the show.  She is now a three-time nominee (2016/2018/2019) and received a Gracie Award (Actress in a Breakthrough Role) in 2018.  Her performance has been hailed by critics as breakthrough and more than just good acting, its a freakin magic trick.  Buzzfeed ranked her performance as the most criminally underrated of the 2010s.

Murphy wrote, produced, and acted in The Plateaus, a CBC web series, which also features Elisha Cuthbert, Jay Baruchel, Sam Roberts, and Kevin MacDonald.  She is a graduate of both the Canadian Film Centre Actors Conservatory and the Theatre Performance Program at Concordia University.  She resides in Toronto, Ontario and was born in Ottawa. 

Murphy is a CARE Canada Ambassador and travelled to Jordan in September 2019 to highlight the issues women, girls, and Syrian refugees are facing.