Sean O'Neill is the Director, Public Programs & Cultural Partnerships at the Art Gallery of Ontario, where he has worked since 2008. At the AGO, he launched the Gallery's successful First Thursday series, and led the creation of projects including the National Ballet collaboration The Dreamers Ever Leave You(2016) and Creative Minds, a bi-annual series of events at Massey Hall, and livestreamed by the CBC, that bring together artists to discuss urgent social issues. O'Neill grew up acting part-time on Canadian productions like Degrassi: The Next Generation and as a host of the children's program Kids TV. From 2015 to 2017, Sean hosted Crash Gallery on CBC.

Sean O'Neill is the host of the 2018 CBC Arts series, In The Making.