Researchers tout 'major scientific discovery' in $14M study for COVID-19 treatment - Action News
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Montreal

Researchers tout 'major scientific discovery' in $14M study for COVID-19 treatment

Researchers at the Montreal Heart Institute have released findings that suggest that the use of colchicine is effective at reducing a person's chances of dying and being hospitalized because of COVID-19.

Close to 4,500 people participated in the study, lead researcher calls findings 'substantial' and 'robust'

The $14-million study was funded by the Quebec government and several organizations. (Ivanoh Demers/Radio-Canada)

Nearly a year after launching a clinical study into a potential COVID-19 treatment, researchers with the Montreal Heart Institute suggest a widely available anti-inflammatory drug is effective in helping people stay away from hospitals and survive the disease.

Nearly 4,500people took part in astudy that's led to what the researchers are calling "a major scientific discovery."

During the study, researchers found that colchicine reduced the chanceof death or hospitalization by 21 per cent when compared to a placebo results researchers said"approached statistical significance."

That number went up when specifically looking at the pool of about 4,200 participants whose COVID-19 diagnoses were confirmed by apolymerase chain reaction(PCR) test. Within that group, researchers say colchicine reduced hospitalizations by 25 per cent and deaths by 44 per cent. They also found the drug helped cut the need for mechanical ventilation by 50 per cent.

The study has yet to be published in a peer-reviewed journal.

"These results are substantial, they are robust, and we believe are compelling to justify the use of the colchicine," said Dr. Jean-Claude Tardif, director of the Montreal Heart Institute'sresearch centre.

"I believe this will have a fairly swift impact on how we practice medicine for patients that have COVIDand are not yet hospitalized."

Researchers with the Montreal Heart Institute say their findings suggest colchicine reduces the chances of death and hospitalizations for someone with COVID-19. (Ryan Remiorz/The Canadian Press)

Dr. Donald Vinh, an infectious diseases specialist with the McGill University Health Centre, is encouraged by the data, though he stresses the need to wait for itto be published.

"First, we need to have the data published so that it can be thoroughly vetted," he said. "Nonetheless, these are very exciting results, and they may potentially provide us with another reason for cautious optimism, here, as we tried to get control over COVID."

Vinh also said the study may provide more information as to which types of patientcan benefit from colchicine, pointing out that some people may not be able to take it.

The study, calledCOLCORONA, was launched last March and cost $14 million.

It includes hundreds of subjects whose COVID-19 diagnoses were not confirmed by PCR tests because those tests were not as widespread at the time, Tardif said.

Tardif also said the initial goal was to recruit 6,000 participants, but researcherssettled on a lower number due to the urgency of the situation.

"The beauty of colchicine is it's already available in pharmacies. So, if a physician reads this today, and has a patient that is at risk of complications, that physician can very well prescribe colchicine today," Tardif said. "This is the reason we felt compelled to alert the population and the medical community immediately about these findings."

Researchers are preparing to publish their findings in a scientific journal.

Thestudy was funded by the Quebec government and several other organizations, and was carried out without contact, with participants from Canada, the United States, South America and South Africa remaining at home.

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