N.L. lab head quits after drug error fiasco

Dr. Nash Denic has resigned ashead of laboratory services at Newfoundland and Labrador's largest health authority aftera drug-testing fiasco in whichlab officials areaccused of reactingto the problem too slowly.

Eastern Health CEO Vickie Kaminski made the announcement at a news conference in St. John's on Wednesday. She said Denic will remain with Eastern Health buthis newrolehas not been determined.

Two other lab staff members have come under special scrutiny. Kaminski said one has been given a desk job pending a review of his work and another has been given a letter of reprimand.

In late February,the health authority announcedthathundreds of patients may have been given too muchcyclosporine, a drug thatcan cause kidney damage in excess dosage.

An internal review of what went wrong, released Tuesday, found that a machine at the Health Sciences Centre in St. John'sthatmeasures blood levels of the drug was not properly calibrated.

People in the lab began raising questions about the results they were seeing in January. In mid-February the lab began reviewing allpatients in the province receiving cyclosporine, an immunosuppressant widely used in organ transplants.

Kaminski said last weekthat she wasn't toldabout the problem until Feb. 19, when a 14-year-old receivingcyclosporine was admitted to intensive care in critical condition.

Kaminski confirmed the boywas given too much of the drugand as of Tuesday he was still in intensive care.

Health Minister Jerome Kennedy, who was also at the news conference, said the drug-testing errors have had a serious impact.

"Right now, my confidence is shaken," Kennedy said. "I will say to you today, there will be accountability and if I were sitting in a senior management job in Eastern Health right now, I'd be watching myself closely to ensure that I haveI know that I read Cameron and understand Cameron. I expect that there will be further changesbut the day is finished when people will not comply with basic requirements such as occurrence and adverse event reporting."

This latest lab trouble comes a year after an inquiryinto errors at another Eastern Health laboratory.

The report on the inquiry into hormone receptor tests for breast cancer patients recommended sweeping changes of Eastern Health's laboratory services.The Inquiry, led byNewfoundland Supreme Court of Appeal Justice MargaretCameron, emphasized the importance of formallydocumenting lab errors in occurance reports.

On Tuesday, an internal review of how errors occurred in cyclosporine testing said the lab didn't follow the health authority's occurrence reporting policies