Poverty leaves its mark on DNA, researchers find

Adults who grew up in poverty show changes in the"programming" oftheir DNA that may be linked to health problems such as obesity and autoimmune diseases, Canadian and British researchers have found.

Researchers had previously known that DNA is "programmed" in the womb to turn certain genes up or down, and more recently have shown that some programming can continue into childhood and adulthood.

But the study published online this week in the International Journal of Epidemiology is the first to show an actuallink between a person's early economic circumstances and the biochemistry ofthat person'sDNA, said Moshe Szyf, a professor of pharmacology at McGill University, who co-authored the study with colleagues at the University of British Columbia and the UCL Institute of Child Health in London.

The researchers examined the DNA in the blood of a group of 40 45-year-old Brits who had been part of an ongoing study since birth. Because of that, the researchers knew whether theygrew up inrich or poor familiesas well asother information about them.

The researchers were looking for a chemical marker called a methyl group that is added to the DNA in certain places through a process known as methylation. That turns genes up or down, meaningthey become more or less activated, a phenomenon known as epigenetics.

Adaptation to changing world

"Our DNA is old and it doesn't always fit to the kind of world we're going to live in," Szyf told CBC's Quirks & Quarks in an interview Saturday.

Scientists think a child's DNA methylation respond to signals both before and after birth about what kind of gene function it will need. For example, a child born into a world with plentiful food will not need the ability to store as much food as fat as a child born into a world of famine, Syzf said.

In the study group, those participants who were raised in difficult economic circumstances showedDNA patterns in whichgroups of genes changed in ways that would have traditionally helped humans adapt toimpoverished environments.

For example, there were changesthat could boost activity inimmunity genes, which did not surprise researchers, because traditionally people who lived in poverty were exposed to lots of disease.

"They see the signal from the mother as being 'it's going to be a harsh world, there's going to be a lot of bacteria around, prepare yourself,'" Syzf said.

He added that the impact of poverty during childhood on the DNA methylation was found to be much greater than the impact of a person's economic circumstances as an adult, or other factors such as whetherthe mother smoked while pregnant.

Some health problems, such as autoimmune diseases (where a person's immune system attacks their own body), may be common among poor people now because they livedifferently than poor people in the past, Syzf suggested. For example,today's less well off exist in amuch cleaner environment, at least in most Western societies.

"Essentially, you have an immune system that's programmed to deal with something that was anticipated but never happens. And now that immune system starts working against itself."

Syzf said the hope is that early intervention to help poor families could protect children from the response that marks their DNA for life.

He added that researchers now have the tools to test whether such intervention has, in fact, worked.

As well, he said, most drug companies are already working on drugs that can affect methylation, which is chemically reversible.