At least 3,124 people in the United States died from COVID-19 on Wednesday, a grim new record as the country grapples with the worst phase of the pandemic thus far.

Johns Hopkins University reported the figure late Wednesday amid a surge in infections around the nation following the Thanksgiving Day holiday period. More than 220,000 people tested positive for the coronavirus on Wednesday alone, and U.S. hospitals have already begun reporting a frightening limit in intensive care beds.

The country last broke the daily record for coronavirus fatalities last Wednesday, when over 2,800 people died from the virus, surpassing a record of about 2,600 deaths set in mid-April when the U.S. was scrambling early in the pandemic. COVID-19 cases are still rising in almost every state.

More than 289,000 people have now died from the virus in America, and the country is on track to surpass 300,000 deaths by the end of the year.