Climate change is first and foremost a health crisis, and the negative effects of extreme heat, wildfires and droughts on people are varied and widespread, according to a new report.

In a climate report released this week, researchers with the medical journal The Lancet warned that the warming climate will affect every U.S. region and there is no safe global temperature rise from a health perspective.

The annual report looked at three interrelated hazards that are amplified by climate change heat, droughts and wildfires and the threats they pose to humans, from worsening mental health to increased risk of heart and lung issues.

While everyones health is already at risk, some populations bear a greater burden, the report said, noting that decades of racially biased policies place Black, Latinx, Asian and Native people, as well as low-income communities, at disproportionately high risk amid the climate crisis.