Willie Nelson is going to creative lengths to mark his favorite unofficial holiday while in self-isolation.

The country music icon will host a livestreamed variety show, Come and Toke It , on Monday in honor of 4/20, or Weed Day. The cannabis-centric music, food, education and comedy event will feature appearances by a host of stars, including Kacey Musgraves, Matthew McConaughey, Jeff Bridges and Billy Ray Cyrus, among others.

Fittingly, the event will kick off at 4:20 p.m. Central time, and run for exactly four hours and 20 minutes. Proceeds will benefit the Last Prisoner Project , a Colorado-based nonprofit that advocates for the decriminalization of marijuana.

Nelson, 86, announced the event on his Instagram on Saturday.