WASHINGTON (AP) The Supreme Court will again wade into the fractious issue of abortion this week when it hears arguments over a medication used in the most common way to end a pregnancy , a case with profound implications for millions of women no matter where they live in America and, perhaps, for the race for the White House.

Two years after the Supreme Court overturned Roe v. Wade and cleared the way for bans or severe restrictions on abortion in many Republican-led states, abortion opponents on Tuesday will ask the high court to ratify a ruling from a conservative federal appeals court that would limit access to the medication mifepristone, which was used in nearly two-thirds of all abortions in the United States last year.

That decision to reverse Roe had immediate political consequences, with Democrats making the case that the court had taken away a right that women held for half a century and winning elections as a result. Even conservative-leaning states like Kansas and Ohio voted against abortion restrictions. If the court were to uphold restrictions on medication abortions it could roil the election landscape in races for Congress and the presidency.

By rolling back Food and Drug Administration changes to the use of mifepristone, the ruling would cut off access to the drug through the mail and impose other restrictions, even in states where abortion remains legal. The restrictions would shorten the time when mifepristone can be used in pregnancy, to seven weeks from 10 currently.

Most adults in the U.S., 55%, believe medication abortion pills are very or somewhat safe when taken as directed by a doctor, according to a KFF poll from May 2023, and 65% have a lot or some confidence in the FDA to ensure that medications sold in the U.S. are safe and effective.

A decision should come by late June. But no matter the outcome, the Supreme Court has not seen its last abortion case. Legal battles are pending over state restrictions, and new federal limits are likely if former President Donald Trump , Republicans presumptive nominee for 2024, returns to the White House.